This is experimental treatment derived from applied experimental medicine publications, single case reports, smaller studies, combined with extensive research on the pharmacokinetic profiles of treatment compounds, personal experience. No doctor or trained practitioner has approved of any of the contents. Do not self-medicate and go to a doctor.
21 Therapeutic Components Available
Comprehensive multimodal system with documented synergistic interactions, individualized selection based on disease stage and patient factors
Antioxidant multimodal therapy, when implemented safely and responsibly, presents minimal risk as the therapeutic approach fundamentally aims to restore cellular functioning and physiological balance. With appropriate biomarker monitoring, this therapy, particularly when combined with orthomolecular medicine or similar integrative practices, holds significant potential for addressing both acute and chronic pathological manifestations while optimizing individual health based on specific bodily and environmental realities.
The therapeutic potential ranges from minimal intervention to potentially complete healing, yet systemic medical realities have resulted in limited awareness of this emerging field. Andrological specialization often emphasizes surgical solutions which, while admittedly viable and sometimes the only option in certain cases, may not always be the optimal first-line approach.
The clinical reports underpinning this model have validated several critical hypotheses:
Personal Perspective: As a 29-year-old affected by this condition, bearing personal responsibility for navigating complex medical decisions, I conclude that surgial correction should only be considered after:
The risk-benefit analysis is clear: surgical risks vastly outweigh those of antioxidant therapy, while the therapeutic benefits appear as promising as the risks are manageable.
Comprehensive Treatment Approach: Effective treatment requires understanding Peyronie's disease as a chronic systemic inflammatory condition. Optimal outcomes benefit from consultation with:
Treatment individualization could greatly benefit from understanding genetic research, circadian rhythms, pharmacokinetics, and environmental factors influencing cellular mechanisms involved in the pathology.
The treatment ultimately depends on the patient's willingness to strictly follow protocols over potentially years.
⚠️ To patients considering surgery: I strongly recommend pausing to consult specialists who understand this pathology's systemic nature. Trial a comprehensive protocol for several months, based on doctors recommendations, even if experiencing pain, as topical diclofenac (potentially not yet prescribed) is included in this approach, which you could try in order to protect yourself from chronic oral NSAID intake. Additionally, expert-guided ESWT (Extracorporeal Shock Wave Therapy) may enhance protocol efficacy when tailored to your specific manifestation.
Important Disclaimer: This website has no affiliation with Dr. Gianni Paulis whatsoever. This protocol is not Dr. Paulis' direct treatment approach, nor does it represent how he would individually tailor therapy based on his irreplaceable clinical expertise and decades of patient experience.
Dr. Paulis holds degrees in Medicine and Surgery from the University La Sapienza in Rome, Italy, and is a specialist in Urology (Rome) and Endocrinology-Andrology (Pisa). He currently serves as Andrologist Consultant at the Regina Apostolorum Hospital in Rome, where he directs the Center of Andrology and heads the "Center for the Treatment of Peyronie's disease." As one of Italy's most experienced Peyronie's specialists, Dr. Paulis is author/coauthor of more than a hundred papers in international journals and has been an invited speaker at numerous national and international congresses.
Dr. Paulis had to be acknowledged because his pioneering research, beginning in 1991 and spanning over three decades, forms the foundational pillar of this educational model. His work on oxidative stress mechanisms and antioxidant treatment protocols provides the core scientific framework upon which this representation is built.
This educational visualization extends Dr. Paulis' foundational research with additional scientific literature mapping, personal disease experience insights, and comprehensive pathway analysis. The goal is to better inform patients and healthcare providers about multimodal treatment approaches during a time when surgery is often portrayed as the only viable option. However, depending on disease stage and individual presentation, this may not hold true when patient satisfaction is the primary measure, 70% plaque regression can equal 100% patient satisfaction in many cases.
📝 How to Submit: Fork the repository → Make data additions in JSON format → Include citation/evidence → Submit pull request
"Together, we can democratize medical knowledge and empower patients worldwide to make informed treatment decisions, pioneering new open-source and AI mediated clinical treatment and data collection models fitting for our age, while at the same time healing the worlds penisses one at a time, or getting better at discovering how, because happy penis happy mind."
Open Source • Non-Commercial License • Patient-Driven Research