AN OVERVIEW AND EXPERIMENTAL CALCULATOR FOR PEYRONIE'S DISEASE

Created by 29-year-old male Peyronie's patient | Multimodal intervention protocol | 6-48 month treatment

OXIDATIVE STRESS CASCADE

CHRONIC EMOTIONAL STRESS

ENVIRONMENTAL STRESS

MECHANICAL STRESS

GENETIC MODIFIERS

IMMUNOLOGICAL STRESS

Genetic Immune Variants:
Infections & Oxidative Stress:

INFLAMMATORY PATHWAY

PROLACTIN

ROS GENERATION

ANTIOXIDANT + STRESS NETWORK

Vitamin E (600-800 IU) + Vit C (1500mg)
SOD (140 IU) → H₂O₂
NAC (600mg) + Silymarin (240mg)
GSH synthesis ↑2.5x
↕ GSH Synergy
Selenium (200μg) → GPx cofactor
Complete peroxide elimination
STRESS MANAGEMENT
Meditation + breathwork

NF-κB ACTIVATION

CYTOKINE RELEASE

Propolis (600-700mg)
Boswellia (200mg)
Diclofenac gel (16mg)
Omega-3 Complex (2.5g)
L-Citrulline (3g)
Vitamin D3+K2 (4000 IU+100µg)
Curcumin+Piperine (1000mg+10mg)
Vitamin B Complex (50mg)
Magnesium Glycinate (500mg)
Olive Oil (50ml)

FIBROTIC TRANSFORMATION

TGF-β1 ACTIVATION

↑ 3-5 fold in fibrosis

NO/cGMP DYSFUNCTION

Pentoxifylline (800mg)
TGF-β1 ↓65%, Collagenase ↑2x
Silymarin (240mg)
L-Carnitine (1000-1500mg)

VASCULAR SUPPORT

Ginkgo Biloba (250mg)
↕ Vascular Synergy 40%
Bilberry (160mg)
Microcirculation ↑40%
Topical Pentoxifylline (5%)
Blood viscosity ↓15%
Omega-3 Complex (2.5g)
L-Citrulline (3g)
Vitamin D3+K2 (4000 IU+100µg)
Tadalafil (5mg)

MYOFIBROBLAST DIFFERENTIATION

COLLAGEN SYNTHESIS

MMP/TIMP IMBALANCE

MITOCHONDRIAL RESCUE

CoQ10 (100mg) + L-Carnitine
BioPerine (10mg)
Zinc (30mg)
Copper (2mg)
Omega-3 Complex (2.5g)
L-Citrulline (3g)
Curcumin+Piperine (1000mg+10mg)

DISEASE MANIFESTATION

TUNICA, CORPORA & PARENCHYMAL FIBROSIS

Tunica Albuginea:
Corpus Cavernosum:
Clinical Manifestations:

Treatment Overview

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EXPERIMENTAL TREATMENT ALERT

This is experimental treatment derived from applied experimental medicine publications, single case reports, smaller studies, combined with extensive research on the pharmacokinetic profiles of treatment compounds, personal experience. No doctor or trained practitioner has approved of any of the contents. Do not self-medicate and go to a doctor.

Constantly under development. Please report mistakes, errors, broken URLs, misinformation/misrepresentation or else to ipp-report@proton.me. Only apply this therapeutic model if you have Peyronie's and your urologist approved it and has looked into it.
My individual right to privacy of medical information outweighs any responsibility for displaying personal contact details beyond the provided email. This site serves purely educational purposes, collects no cookies or personal data, and presents content derived exclusively from publicly available scientific information arranged in this educational format.
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Key Mechanisms

  • TGF-β1 Modulation: Multi-pathway regulation
  • Collagen Balance: ECM remodeling enhancement
  • Oxidative Stress: ROS/antioxidant equilibrium
  • Inflammation: Multiple pathway inhibition
  • Fibrosis: MMPs activation, TIMPs inhibition
⚖️ Cellular Redox Homeostasis Balance
Critical Balance: Optimal therapeutic window requires careful antioxidant dosing. Excessive supplementation can disrupt cellular signaling and paradoxically worsen fibrosis. Individualized protocols based on biomarkers are essential.
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Core Protocol

21 Therapeutic Components Available

Comprehensive multimodal system with documented synergistic interactions, individualized selection based on disease stage and patient factors

Core Antioxidants Anti-inflammatory Agents Vascular Modulators
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Safety Profile

Generally well-tolerated compounds with established safety profiles
⚠️ Regular monitoring of liver/kidney function recommended
⚠️ Drug interactions require medical supervision
⚠️ 6-48 month treatment duration based on response

Advanced Treatment Calculator

Patient Profile

BMI BMI: 24.5

Treatment Components

Personalized Results

Therapy Components

Oral Supplements
Topical Applications

Best Case Response Potential

  • Reduced pain
  • Reduced systemic inflammation
  • Curvature improvement
  • Plaque regression
  • Calcification absorption
  • Tissue remodeling
  • Improved mood
  • Improved energy

Worst Case Potential Risks

Harming redox-homeostasis through excessive antioxidant overload
Monitor: GSH:GSSG ratio
Preventative measure: 1 day/week off protocol
Unique genetic metabolism
Risk: May require heavy component and dosage adjustment based on genetic traits that directly affect antioxidant therapy variables
Preventative measure: Conduct genetic testing and consult with specialist regarding dosage adjustments and intake practice
Environmental factors
Adjust protocol based on: Alcohol, coffee, heavy sun exposure, psychological stress level, medications
Absolute Contraindications
DO NOT use this protocol if you have: Autoimmune disease, liver failure, cancer, or other major system impairments
Risk: Unknown, extreme risks - protocol should NOT be deployed at all

Stage Recommendations

Important Medical & Therapeutic Disclaimer

Antioxidant multimodal therapy, when implemented safely and responsibly, presents minimal risk as the therapeutic approach fundamentally aims to restore cellular functioning and physiological balance. With appropriate biomarker monitoring, this therapy, particularly when combined with orthomolecular medicine or similar integrative practices, holds significant potential for addressing both acute and chronic pathological manifestations while optimizing individual health based on specific bodily and environmental realities.

The therapeutic potential ranges from minimal intervention to potentially complete healing, yet systemic medical realities have resulted in limited awareness of this emerging field. Andrological specialization often emphasizes surgical solutions which, while admittedly viable and sometimes the only option in certain cases, may not always be the optimal first-line approach.

The clinical reports underpinning this model have validated several critical hypotheses:

  1. Finding 1: A specific combination of substances and bodily conditions facilitates fibrosis, plaque and calcification regression, demonstrating the body's inherent capacity for complete resolution when multiple pathological factors are properly addressed.
  2. Finding 2: Clinical studies strongly suggest that holistic interaction of multiple therapeutic components (within reasonable limits) correlates with improved healing outcomes.
  3. Finding 3: Individualized compilation of therapeutic substances yields superior results, a logical conclusion for treating systemic conditions through comprehensive repair approaches that must account for individual physiological variations.

Personal Perspective: As a 29-year-old affected by this condition, bearing personal responsibility for navigating complex medical decisions, I conclude that surgial correction should only be considered after:

  • Comprehensive trial of multimodal, monitored antioxidant therapy
  • Or in extremely severe cases where regression is logically impossible

The risk-benefit analysis is clear: surgical risks vastly outweigh those of antioxidant therapy, while the therapeutic benefits appear as promising as the risks are manageable.

Comprehensive Treatment Approach: Effective treatment requires understanding Peyronie's disease as a chronic systemic inflammatory condition. Optimal outcomes benefit from consultation with:

  • Urologists and andrologists
  • Endocrinologists
  • Internal medicine specialists
  • Orthomolecular medicine practitioners
  • Rheumatology/immunology experts
  • Specialists in cellular and molecular mechanisms

Treatment individualization could greatly benefit from understanding genetic research, circadian rhythms, pharmacokinetics, and environmental factors influencing cellular mechanisms involved in the pathology.

The treatment ultimately depends on the patient's willingness to strictly follow protocols over potentially years.

⚠️ To patients considering surgery: I strongly recommend pausing to consult specialists who understand this pathology's systemic nature. Trial a comprehensive protocol for several months, based on doctors recommendations, even if experiencing pain, as topical diclofenac (potentially not yet prescribed) is included in this approach, which you could try in order to protect yourself from chronic oral NSAID intake. Additionally, expert-guided ESWT (Extracorporeal Shock Wave Therapy) may enhance protocol efficacy when tailored to your specific manifestation.

⚠️ Medical Disclaimer:This information is for educational purposes only and does not constitute medical advice. Always consult qualified healthcare professionals before making treatment decisions. Individual results may vary significantly based on numerous factors.

Special Contribution Literature

Important Disclaimer: This website has no affiliation with Dr. Gianni Paulis whatsoever. This protocol is not Dr. Paulis' direct treatment approach, nor does it represent how he would individually tailor therapy based on his irreplaceable clinical expertise and decades of patient experience.

Dr. Paulis holds degrees in Medicine and Surgery from the University La Sapienza in Rome, Italy, and is a specialist in Urology (Rome) and Endocrinology-Andrology (Pisa). He currently serves as Andrologist Consultant at the Regina Apostolorum Hospital in Rome, where he directs the Center of Andrology and heads the "Center for the Treatment of Peyronie's disease." As one of Italy's most experienced Peyronie's specialists, Dr. Paulis is author/coauthor of more than a hundred papers in international journals and has been an invited speaker at numerous national and international congresses.

Dr. Paulis had to be acknowledged because his pioneering research, beginning in 1991 and spanning over three decades, forms the foundational pillar of this educational model. His work on oxidative stress mechanisms and antioxidant treatment protocols provides the core scientific framework upon which this representation is built.

This educational visualization extends Dr. Paulis' foundational research with additional scientific literature mapping, personal disease experience insights, and comprehensive pathway analysis. The goal is to better inform patients and healthcare providers about multimodal treatment approaches during a time when surgery is often portrayed as the only viable option. However, depending on disease stage and individual presentation, this may not hold true when patient satisfaction is the primary measure, 70% plaque regression can equal 100% patient satisfaction in many cases.

Key Publications by Dr. Paulis et al. in Our Database:

  • "Effectiveness of antioxidants (propolis, blueberry, vitamin E) associated with verapamil in the medical management of Peyronie's disease: A study of 151 cases"
    Paulis G, Cavallini G, De Giorgio G, et al. - Int J Androl. 2012;35(4):521-527
  • "Patients with Peyronie's disease achieve complete plaque regression after multimodal treatment with antioxidants: a case series"
    Paulis G, De Giorgio G, Paulis L - J Med Case Rep. 2022;16(1):379
  • "Rationale of combination therapy with antioxidants in medical management of Peyronie's disease: results of clinical application"
    Paulis G, Romano G, Paulis A, Barletta D - Res Rep Urol. 2017;9:129-139
  • "Recent Pathophysiological Aspects of Peyronie's Disease: Role of Free Radicals, Rationale, and Therapeutic Implications for Antioxidant Treatment - Literature Review"
    Paulis G - Adv Urol. 2017;2017:4653512
  • "Role of Oxidative Stress in Peyronie's Disease: Biochemical Evidence and Experiences of Treatment with Antioxidants"
    Paulis G, Paulis A, Romano G, et al. - Int J Mol Sci. 2022;23(24):15969

🚀 Platform Development Roadmap

🔬 Research Extensions

  • Genetic Variants: SOD2, GSTM1/GSTT1, GPX1 integration
  • Environmental Factors: Quantification models
  • Biomarkers: Metabolic correlations & tracking
  • Circadian Biology: Timing optimization algorithms

💻 Technical Features

  • Progress Tracking: Patient journey monitoring
  • Export System: PDF/CSV protocol generation
  • Data Collection: Anonymized outcome framework
  • AI Integration: LLM-ready custom-knowledge, chatbot interface

Priority Wishlist

  • Mobile Optimization: Mobile friendly interface, (but how the visualization then)
  • ESWT Protocol: Shockwave therapy integration
  • Image Analysis: Plaque/curvature tracking
  • Ultrasound AI: Enhance ultrasound disease and stage recognition with AI processing (inspiration: https://github.com/anitoanto/alus-package)
  • Community Forum: Patient support network, we are all living in the shadows, most doctors do not even know what the disease is, yet 2-9% of us men are affected. To put this into perspective, only 0.4% of men develop testicular cancer, yet this disease is sometimes even known to children, much less doctors.

🌍 Every Profession Can Contribute

💊 Pharmacologists
  • Update pharmacokinetic parameters (ka, tmax, f, vd, halfLife)
  • Refine dose adjustments for renal/hepatic impairment and other risks
  • Add drug-food interaction data
  • Validate bioavailability percentages
🧬 Geneticists
  • Add CYP450 enzyme polymorphism adjustments
  • Create metabolizer phenotype dosing (poor/rapid)
  • Map SOD2, GSTM1, GPX1 variant impacts
  • Design pharmacogenomic algorithms
🔬 Clinical Researchers
  • Contribute anonymized trial outcome data
  • Validate effectiveness percentages
  • Add new stage-specific protocols
  • Report adverse event frequencies
🧪 Biochemists
  • Map component-component interactions (3-7+ hop chains)
  • Calculate synergy factors and CI values
  • Document reaction rate constants
  • Add pathway mechanism descriptions
📊 Data Scientists
  • Build predictive outcome models
  • Create clustering algorithms for patient types
  • Develop interaction network visualizations
  • Implement machine learning dose optimization
🏥 Urologists/Andrologists
  • Validate clinical presentation classifications
  • Add imaging correlation data
  • Contribute ESWT protocol parameters
  • Document surgical outcome comparisons
💻 Developers
  • Build mobile applications
  • Create API endpoints for data access
  • Implement progress tracking systems
  • Develop export/reporting features
🤖 AI/LLM Enthusiasts
  • Find and validate new citations
  • Synthesize research across papers
  • Debug calculation algorithms
  • Create chatbot interfaces
📚 Literature Reviewers
  • Add citations to citations/ folder
  • Update verification URLs
  • Cross-reference contradictory findings
  • Compile meta-analysis data
🧑‍⚕️ Nutritionists
  • Add dietary interaction factors
  • Document optimal timing protocols
  • Create food-supplement synergies
  • Design circadian dosing schedules
👥 Patients
  • Share anonymized outcome data
  • Report side effects and tolerability
  • Document quality of life improvements
  • Contribute imaging progression data
💰 Investors/Philanthropists
  • Fund development of new features
  • Support clinical validation studies
  • Enable server infrastructure
  • Sponsor translation efforts

📝 How to Submit: Fork the repository → Make data additions in JSON format → Include citation/evidence → Submit pull request

"Together, we can democratize medical knowledge and empower patients worldwide to make informed treatment decisions, pioneering new open-source and AI mediated clinical treatment and data collection models fitting for our age, while at the same time healing the worlds penisses one at a time, or getting better at discovering how, because happy penis happy mind."

Open Source • Non-Commercial License • Patient-Driven Research